Momtezuma Tuatara
07-03-10, 12:23 PM
http://www.journals.uchicago.edu/doi/abs/10.1086/651079
MAJOR ARTICLE
Increased Risk of Hospitalization for Acute Lower Respiratory Tract Infection among Australian Indigenous Infants 5–23 Months of Age Following Pneumococcal Vaccination: A Cohort Study
Kerry‐Ann F. O’Grady,1
Katherine J. Lee,2,3
John B. Carlin,2,3
Paul J. Torzillo,4,5,9
Anne B. Chang,1,6
E. Kim Mulholland,1,10
Stephen B. Lambert,7,8 and
Ross M. Andrews1
1Child Health Division, Menzies School of Health Research, Charles Darwin University, Tiwi, 2Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, Royal Children’s Hospital, and 3Department of Paediatrics, University of Melbourne, Melbourne, 4Department of Respiratory Medicine, Royal Prince Alfred Hospital, University of Sydney, and 5South West Sydney Area Health Service, Sydney, 6Queensland Children’s Respiratory Centre and 7Queensland Paediatric Infectious Diseases Laboratory, Queensland Children’s Medical Research Institute, Royal Children’s Hospital, and 8Clinical Medical Virology Centre, Sir Albert Sakzewski Virus Research Centre, University of Queensland, Brisbane, and 9Nganampa Health Service, Anangu Pitjantjatjara Yankunytjatjara, Australia; and 10London School of Hygiene and Tropical Medicine, London, England
Background.http://www.journals.uchicago.edu/na101/home/literatum/publisher/uchicago/journals/entities/2003.gifAustralian Indigenous children are the only population worldwide to receive the 7‐valent pneumococcal conjugate vaccine (7vPCV) at 2, 4, and 6 months of age and the 23‐valent pneumococcal polysaccharide vaccine (23vPPV) at 18 months of age. We evaluated this program’s effectiveness in reducing the risk of hospitalization for acute lower respiratory tract infection (ALRI) in Northern Territory (NT) Indigenous children aged 5–23 months.
Methods.http://www.journals.uchicago.edu/na101/home/literatum/publisher/uchicago/journals/entities/2003.gifWe conducted a retrospective cohort study involving all NT Indigenous children born from 1 April 2000 through 31 October 2004. Person‐time at‐risk after 0, 1, 2, and 3 doses of 7vPCV and after 0 and 1 dose of 23vPPV and the number of ALRI following each dose were used to calculate dose‐specific rates of ALRI for children 5–23 months of age. Rates were compared using Cox proportional hazards models, with the number of doses of each vaccine serving as time‐dependent covariates.
Results.http://www.journals.uchicago.edu/na101/home/literatum/publisher/uchicago/journals/entities/2003.gifThere were 5482 children and 8315 child‐years at risk, with 2174 episodes of ALRI requiring hospitalization (overall incidence, 261 episodes per 1000 child‐years at risk). Elevated risk of ALRI requiring hospitalization was observed after each dose of the 7vPCV vaccine, compared with that for children who received no doses, and an even greater elevation in risk was observed after each dose of the 23vPPV (adjusted hazard ratio [HR] vs no dose, 1.39; 95% confidence interval [CI], 1.12–1.71; http://www.journals.uchicago.edu/na101/home/literatum/publisher/uchicago/journals/production/cid/2010/50/7/651079/images/eqs/eq-00001.gif ). Risk was highest among children vaccinated with the 23vPPV who had received <3 doses of the 7vPCV (adjusted HR, 1.81; 95% CI, 1.32–2.48).
Conclusions.http://www.journals.uchicago.edu/na101/home/literatum/publisher/uchicago/journals/entities/2003.gifOur results suggest an increased risk of ALRI requiring hospitalization after pneumococcal vaccination, particularly after receipt of the 23vPPV booster. The use of the 23vPPV booster should be reevaluated.
MAJOR ARTICLE
Increased Risk of Hospitalization for Acute Lower Respiratory Tract Infection among Australian Indigenous Infants 5–23 Months of Age Following Pneumococcal Vaccination: A Cohort Study
Kerry‐Ann F. O’Grady,1
Katherine J. Lee,2,3
John B. Carlin,2,3
Paul J. Torzillo,4,5,9
Anne B. Chang,1,6
E. Kim Mulholland,1,10
Stephen B. Lambert,7,8 and
Ross M. Andrews1
1Child Health Division, Menzies School of Health Research, Charles Darwin University, Tiwi, 2Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, Royal Children’s Hospital, and 3Department of Paediatrics, University of Melbourne, Melbourne, 4Department of Respiratory Medicine, Royal Prince Alfred Hospital, University of Sydney, and 5South West Sydney Area Health Service, Sydney, 6Queensland Children’s Respiratory Centre and 7Queensland Paediatric Infectious Diseases Laboratory, Queensland Children’s Medical Research Institute, Royal Children’s Hospital, and 8Clinical Medical Virology Centre, Sir Albert Sakzewski Virus Research Centre, University of Queensland, Brisbane, and 9Nganampa Health Service, Anangu Pitjantjatjara Yankunytjatjara, Australia; and 10London School of Hygiene and Tropical Medicine, London, England
Background.http://www.journals.uchicago.edu/na101/home/literatum/publisher/uchicago/journals/entities/2003.gifAustralian Indigenous children are the only population worldwide to receive the 7‐valent pneumococcal conjugate vaccine (7vPCV) at 2, 4, and 6 months of age and the 23‐valent pneumococcal polysaccharide vaccine (23vPPV) at 18 months of age. We evaluated this program’s effectiveness in reducing the risk of hospitalization for acute lower respiratory tract infection (ALRI) in Northern Territory (NT) Indigenous children aged 5–23 months.
Methods.http://www.journals.uchicago.edu/na101/home/literatum/publisher/uchicago/journals/entities/2003.gifWe conducted a retrospective cohort study involving all NT Indigenous children born from 1 April 2000 through 31 October 2004. Person‐time at‐risk after 0, 1, 2, and 3 doses of 7vPCV and after 0 and 1 dose of 23vPPV and the number of ALRI following each dose were used to calculate dose‐specific rates of ALRI for children 5–23 months of age. Rates were compared using Cox proportional hazards models, with the number of doses of each vaccine serving as time‐dependent covariates.
Results.http://www.journals.uchicago.edu/na101/home/literatum/publisher/uchicago/journals/entities/2003.gifThere were 5482 children and 8315 child‐years at risk, with 2174 episodes of ALRI requiring hospitalization (overall incidence, 261 episodes per 1000 child‐years at risk). Elevated risk of ALRI requiring hospitalization was observed after each dose of the 7vPCV vaccine, compared with that for children who received no doses, and an even greater elevation in risk was observed after each dose of the 23vPPV (adjusted hazard ratio [HR] vs no dose, 1.39; 95% confidence interval [CI], 1.12–1.71; http://www.journals.uchicago.edu/na101/home/literatum/publisher/uchicago/journals/production/cid/2010/50/7/651079/images/eqs/eq-00001.gif ). Risk was highest among children vaccinated with the 23vPPV who had received <3 doses of the 7vPCV (adjusted HR, 1.81; 95% CI, 1.32–2.48).
Conclusions.http://www.journals.uchicago.edu/na101/home/literatum/publisher/uchicago/journals/entities/2003.gifOur results suggest an increased risk of ALRI requiring hospitalization after pneumococcal vaccination, particularly after receipt of the 23vPPV booster. The use of the 23vPPV booster should be reevaluated.