T cell change after Measles vax?

[bbrandonsmom]

http://www.ingentaconnect.com/content/ap/ii/1996/00000079/00000002/art00063

So I'm looking at various studies and this one caught my eye. This is not the whole study, but I have a question. They are saying infants 6-9 months old. But Measles isn't given at that age, so are they talking about T cell change from a different vaccine, or did they really use the Measles vax?

[cartersmom]

link did not work for me

[MinorityView]

worked for me, but I'll quote it for you:

Abstract:
Measles produces immune suppression which contributes to an increased susceptibility to other infections. Recently, high titered measles vaccines have been linked to increased long-term mortality among some female recipients. Because the mechanisms by which wild-type or attenuated live-vaccine strains of measles virus alter subsequent immune responses are not fully understood, this prompted an examination of the changes within the peripheral blood T cell receptor V beta repertoire following measles immunization. Twenty-four 6- and 9-month-old infants were studied at 2 weeks and 3 months following immunization by semiquantitative reverse transcription-polymerase chain reaction. There was a significant increase in V beta 2 expression ( P < 0.05), and a decrease in the V beta 4 subset ( P < 0.03) 2 weeks following vaccination with subsequent return to baselines at 3 months in vaccine recipients who seroconverted. These data suggest that measles virus may affect immune responses in part by altering the T cell receptor repertoire.

Language: English
Document Type: Research article
Affiliations: 1: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 2: Department of Pediatrics and Child Health, University of Cape Town, Cape Town, South Africa 3: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 4: National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 5: Department of Molecular Microbiology and Immunology, John Hopkins University School of Hygiene and Public Health, Baltimore, Maryland

[TanyaL]

http://www.ingentaconnect.com/content/ap/ii/1996/00000079/00000002/art00063

So I'm looking at various studies and this one caught my eye. This is not the whole study, but I have a question. They are saying infants 6-9 months old. But Measles isn't given at that age, so are they talking about T cell change from a different vaccine, or did they really use the Measles vax?

I think some areas with high measles prevalence choose to administer MMR early, and then again not too much later--twice in early childhood, not sure if they then do it again just before school-age.

[Momtezuma Tuatara]

Don't you think the price of this article was interesting? $52.00 USA?

Daylight robbery. But that's pharma all over isn't it.

[Nirvana]

In the Indian pediatric vaccine schedule, a measles vaccine is supposed to be given to 9-month-old infants. In fact, most of the babies in India are still given this at nine months and the MMR at 12 months.