Momtezuma Tuatara
24-01-09, 02:03 PM
This is stickied, because people don't realise just how much "bones" are the foundation of our total health.
At some point, I will put up a summary, but I'm not doing that until I know people have thought this through for themselves, (and then... maybe, people can perhaps write the summary for me). I've already written this up for another book not yet published, but what this thread will do is take you back to the process I had to revise when writing for the unpublished book.
first word of warning. Always take medical articles with more than a grain of salt. Read them carefully and evaluate their message. But lets look at what IS known.
(Extra Cellular Matrix, which is a highly technical way of saying the basic superstructure upon which the strengthening minerals will be hung...)
I ain't gonna do all your thinking for you. I will "direct" this thread, so that eventually you will see some logical order in it.
First lesson: Bone Development and Structure. (http://www.nsbri.org/HumanPhysSpace/focus6/ep_development.html) Yes, the URL is there, but I've attached a pdf of the page in case it walks, as internet pages are wont to do.
You might think this page on Biomechanics (http://www.engin.umich.edu/class/bme456/bonestructure/bonestructure.htm) is the same, but it's not and it will give you a much better appreciation of bone, and this article reinforces what those who know me, are sick of me saying: "Bone is also a good starting point because it illustrates the principle of hierarchical structure function that is common to all biological tissues."
(I attempted to upload the pdf of the page, but the site programme has some gliches in it, and won't upload that pdf. I have it in my data base as bonestruct.pdf)
You get your bones wrong, and the whole of the rest of you goes west with it, so look after your bones, and you'll be looking after the rest of you... teeth and soft tissue.
Message Number one.
URL: What YOU eat during your pregnancy, and during lactation (http://jn.nutrition.org/cgi/reprint/135/11/2728S) has long term bone consequences and, "Maternal smoking, diet (particularly vitamin D deficiency), and physical activity also appear to modulate bone mineral acquisition during intrauterine life; furthermore, both low birth size and poor childhood growth are directly linked to the later risk of hip fracture. "
So what you do now as a mum, is very important, and in order to have the incentive to do it right, it's important to know how bone is made (if you are going to grow it/fix it quickly and efficiently).
It's important to know what happens when the mineral balance starts to go wrong. People talk about osteoporosis, but the reality is that osteo only starts, when mineral balances has been out of whack for some time, and much of that can be laid at the door of the food people consider "normal" today.
Doctors only see calcium when it comes to osteo, yet actually they should be seeing Multiple mineral problems, like, boron, magnesium, silica, zinc. ...
I want to talk about "first level cortical bone structure (FLCBS)... which only occurs in two situations. If you've read the bone structure pdf properly, you will know this.
1) Under the age of five.
2) trauma at bone fracture sites.
So "woven bone" is a response to the body needing bone "now". While this bone requires the same building blocks as bone "grown and recycled" over a long period of time, FLCBS bone collagen formation is random.
In constantly turned over bone, the collagen fibrils are is a specific set pattern,not random like woven bone..., which is amazing to see. collagen gives bone flexibility...... and the orientation of the different angle of the fibrils, determines the angle of the holes in which mineral crytals (which give strength) are laid. 80% of those are calcium/phosphorus, but the crucial ones which LOCK IN THOSE TWO, are the minerals, magnesium, boron etc.
this diagramme in the bone structure page, gives and idea of some of the collagen fibril patterns:
http://www.engin.umich.edu/class/bme456/bonestructure/plywood2.jpg
So, first the foundation, which as we KNOW... is... a collagen. You can't make collagen without???
See the pdf below, called Brickley Skeletal manifestations.
Vitamin C is truly the foundation of life, and when you start to understand how many enzyme and other vital processes it starts, is when you begin to realize how deficient is anyone's brain who might accept that an RDA (Recommended Daily Allowance) is 70 mgs a day :rolleyes:
In order make good collagen, you also need chondroitin sulphate and glucosamine, neither of which are much use without a source of.... gelatin. But none of those three can be processed or made without.... vitamin C.
The following highlighted words are all URLs to medical articles all of which look at different aspects:
Rat bone formation is similar to humans, and studies with rats have also shown that any deficient in calcium AND IRON (http://jn.nutrition.org/cgi/content/abstract/132/10/3135), is going to have problems.
"In two human studies, boron deprivation caused changes in variables associated with calcium metabolism in a manner that could be construed as being detrimental to bone formation and maintenance; these changes apparently were enhanced by low dietary magnesium. Changes caused by boron deprivation included depressed plasma ionized calcium and calcitonin as well as elevated plasma total calcium and urinary excretion of calcium. In one human study, magnesium deprivation depressed plasma ionized calcium and cholesterol. Because boron and/or magnesium deprivation (http://www.ncbi.nlm.nih.gov/pubmed/2222801)causes changes similar to those seen in women with postmenopausal osteoporosis, these elements are apparently needed for optimal calcium metabolism and are thus needed to prevent the excessive bone loss which often occurs in postmenopausal women and older men."
"Evidence from numerous laboratories using a variety of experimental models, including humans, shows that boron is a bioactive beneficial element. Much evidence has come from studies that did not require nutritional or environmental stressors or fastidious methods in diet preparation or environmental control. The evidence includes deprivation studies showing that boron is necessary for some higher animals to complete the life cycle, and that realistic low boron intakes result in impaired bone health, brain function, and immune response (http://www.ncbi.nlm.nih.gov/pubmed/18366532). Thus, low boron intake is a relevant nutritional concern, which diets rich in fruits, vegetables, nuts, and pulses can prevent."
"Minerals associated with bone organic matrix, zinc and potassium, were increased by boron supplementation in tibia. Plasma phospholipids were decreased by boron deprivation in females, but not males. Plasma cholesterol was decreased in boron-supplemented males by replacing canola oil with palm oil. The findings suggest that a diet high in omega-3 alpha-linolenic acid promotes femur strength best when the dietary boron is adequate. (http://www.ncbi.nlm.nih.gov/pubmed/15665386)..."
"there is considerable evidence that both compositional and functional properties of bone are affected by boron (http://www.ncbi.nlm.nih.gov/pubmed/7889880)status"
but also impacting on that is Zinc. (http://www.ebmonline.org/cgi/reprint/229/4/303)
Vitamin K (http://jn.nutrition.org/cgi/reprint/125/7/1812), vitamin K (http://www.ajcn.org/cgi/reprint/80/4/1075), and vitamin K applying to both men and women (http://jcem.endojournals.org/cgi/reprint/89/10/4904). which is what you'd expect because vitamin K forms a mineral bond with calcium and phosphorus, and pulls them into that base matrix.
Other dietary components, such as protein, magnesium, zinc, copper, iron, fluoride, vitamins D, A, C, and K (http://www.jacn.org/cgi/content/full/19/6/715) are required for normal bone metabolism,.. more on protein (http://www.jacn.org/cgi/content/full/24/suppl_6/526S). Protein consumption is an important predictor (http://jn.nutrition.org/cgi/content/full/137/12/2674) of lower limb bone density in older women. Protein is important in bone building particularly in vegetarians, because collagen is made from complete amino acids. So vegetarians must take particular care when putting combining foods to create complete amino acids, so that the body can take from it to make collagen. Those who eat chicken, meat etc, have a complete protein handed them on a plate, particularly if they have bone broths, and gelatine broths. Protein in the absense of calcium (http://jn.nutrition.org/cgi/reprint/137/12/2674)(and other minerals) means that it doesn't quite "work"... you might get collagen formatin, but the mineral matrix will be weak. Even tea drinking (http://www.ajcn.org/cgi/content/full/86/4/1243), conveys minerals like manganese, which are beneficial to bones.
http://www.health-science-spirit.com/magnesiumchloride.html
"Medical authorities claim that the widespread incidence of osteoporosis and tooth decay in western countries can be prevented with a high calcium intake. However, published evidence reveals that the opposite is true. Asian and African populations with a very low intake of about 300 mg of calcium daily have very little osteoporosis. Bantu women with an intake of 200 to 300 mg of calcium daily have the lowest incidence of osteoporosis in the world. In western countries with a high intake of dairy products the average calcium intake is about 1000 mg. The higher the calcium intake, especially in the form of cows' milk products (except butter) the higher the incidence of osteoporosis.
Calcium, magnesium and phosphorus levels are kept in a seesaw balance by the parathyroid hormones. If calcium goes up, magnesium goes down and vice versa. With a low magnesium intake, calcium goes out of the bones to increase tissue levels, while a high magnesium intake causes calcium to go out of the tissues into the bones. A high phosphorus intake without a high calcium or magnesium intake causes calcium to leach from the bones and leave the body with the urine. A high phosphorus intake with high calcium and magnesium leads to bone mineralisation.
Dr Barnett, an orthopaedic surgeon practised in two different U.S. counties with very different soil and water mineral levels. In Dallas County with a high calcium and low magnesium concentration osteoporosis and hip fractures were very common, while in Hereford with high magnesium and low calcium these were nearly absent. In Dallas County the magnesium content of bones was 0.5% while in Hereford it was 1.76%. In another comparison the magnesium content in bones of osteoporosis sufferers was 0.62% while in healthy individuals it was 1.26%.
The same applies for healthy teeth. In a New Zealand study it was found that caries-resistant teeth had on average twice the amount of magnesium as caries-prone teeth. The average concentration of magnesium phosphate in bones is given as about 1%, in teeth about 1.5%, in elephant tusks 2% and in the teeth of carnivorous animals made to crush bones it is 5%. In regard to the strength of bones and teeth think of calcium as chalk and of magnesium as superglue. The magnesium superglue binds and transforms the chalk into superior bones and teeth."
Too much preformed vitamin A (http://folk.uio.no/runeb/pdf%20filer/Vitamin%20A%20toxicity.PDF) causes serious bone problems (http://www.ajcn.org/cgi/content/full/83/2/191), but remember, if you are doing the balance with vitamin D, vitamin C and exercise right, that's not an issue (http://jn.nutrition.org/cgi/reprint/129/12/2246.pdf). At least in rats :giggle: .
the key to good strength in bones is vitamin K and minerals from fruit and veges (http://www.ajcn.org/cgi/content/full/82/3/700): no doubt about it.
So why the concentration by doctors on calcium alone? And just how many people on calcium supplements show much real improvement? If you carry on shoving in calcium all the time, you pull OUT the magnesium. If you're not eating enough calcium in the first place, and some doctors estimate that that's 70% of the western population, that too causes pullout of calcium from the bones, which is then depositted in soft tissue, which doesn't just harden the arteries, but can harden heart muscles and do a whole raft of nasty things.
With kids, or adults, you never know when someone is going to break a bone, but if that happens, it's important to know what to do and why.
And to understand what to do and why, you have to know HOW bone is made in the first place. it's actually very fascinating.
Bearing in mind that, as this 2006 study (http://www.ismni.org/jmni/pdf/26/27DALLAS.pdf) says, there is a lot they don't know about bone growth :giggle: :giggle:
these studies suggest that cells within the bone environment may be more dynamic than previously thought and highlight novel cell-mediated mechanisms for the assembly and subsequent reorganization of the ECM.
I believe that the fundamentals above, are probably stuff in retrospect, that you already know yourself.
So if you eat a Standard American Diet, think again, because you might not just be heading for osteo yourself, but you could donate problems to your children.
All that... is called.... epigenetics :p
Now, do not complain of brain fag :D
At some point, I will put up a summary, but I'm not doing that until I know people have thought this through for themselves, (and then... maybe, people can perhaps write the summary for me). I've already written this up for another book not yet published, but what this thread will do is take you back to the process I had to revise when writing for the unpublished book.
first word of warning. Always take medical articles with more than a grain of salt. Read them carefully and evaluate their message. But lets look at what IS known.
(Extra Cellular Matrix, which is a highly technical way of saying the basic superstructure upon which the strengthening minerals will be hung...)
I ain't gonna do all your thinking for you. I will "direct" this thread, so that eventually you will see some logical order in it.
First lesson: Bone Development and Structure. (http://www.nsbri.org/HumanPhysSpace/focus6/ep_development.html) Yes, the URL is there, but I've attached a pdf of the page in case it walks, as internet pages are wont to do.
You might think this page on Biomechanics (http://www.engin.umich.edu/class/bme456/bonestructure/bonestructure.htm) is the same, but it's not and it will give you a much better appreciation of bone, and this article reinforces what those who know me, are sick of me saying: "Bone is also a good starting point because it illustrates the principle of hierarchical structure function that is common to all biological tissues."
(I attempted to upload the pdf of the page, but the site programme has some gliches in it, and won't upload that pdf. I have it in my data base as bonestruct.pdf)
You get your bones wrong, and the whole of the rest of you goes west with it, so look after your bones, and you'll be looking after the rest of you... teeth and soft tissue.
Message Number one.
URL: What YOU eat during your pregnancy, and during lactation (http://jn.nutrition.org/cgi/reprint/135/11/2728S) has long term bone consequences and, "Maternal smoking, diet (particularly vitamin D deficiency), and physical activity also appear to modulate bone mineral acquisition during intrauterine life; furthermore, both low birth size and poor childhood growth are directly linked to the later risk of hip fracture. "
So what you do now as a mum, is very important, and in order to have the incentive to do it right, it's important to know how bone is made (if you are going to grow it/fix it quickly and efficiently).
It's important to know what happens when the mineral balance starts to go wrong. People talk about osteoporosis, but the reality is that osteo only starts, when mineral balances has been out of whack for some time, and much of that can be laid at the door of the food people consider "normal" today.
Doctors only see calcium when it comes to osteo, yet actually they should be seeing Multiple mineral problems, like, boron, magnesium, silica, zinc. ...
I want to talk about "first level cortical bone structure (FLCBS)... which only occurs in two situations. If you've read the bone structure pdf properly, you will know this.
1) Under the age of five.
2) trauma at bone fracture sites.
So "woven bone" is a response to the body needing bone "now". While this bone requires the same building blocks as bone "grown and recycled" over a long period of time, FLCBS bone collagen formation is random.
In constantly turned over bone, the collagen fibrils are is a specific set pattern,not random like woven bone..., which is amazing to see. collagen gives bone flexibility...... and the orientation of the different angle of the fibrils, determines the angle of the holes in which mineral crytals (which give strength) are laid. 80% of those are calcium/phosphorus, but the crucial ones which LOCK IN THOSE TWO, are the minerals, magnesium, boron etc.
this diagramme in the bone structure page, gives and idea of some of the collagen fibril patterns:
http://www.engin.umich.edu/class/bme456/bonestructure/plywood2.jpg
So, first the foundation, which as we KNOW... is... a collagen. You can't make collagen without???
See the pdf below, called Brickley Skeletal manifestations.
Vitamin C is truly the foundation of life, and when you start to understand how many enzyme and other vital processes it starts, is when you begin to realize how deficient is anyone's brain who might accept that an RDA (Recommended Daily Allowance) is 70 mgs a day :rolleyes:
In order make good collagen, you also need chondroitin sulphate and glucosamine, neither of which are much use without a source of.... gelatin. But none of those three can be processed or made without.... vitamin C.
The following highlighted words are all URLs to medical articles all of which look at different aspects:
Rat bone formation is similar to humans, and studies with rats have also shown that any deficient in calcium AND IRON (http://jn.nutrition.org/cgi/content/abstract/132/10/3135), is going to have problems.
"In two human studies, boron deprivation caused changes in variables associated with calcium metabolism in a manner that could be construed as being detrimental to bone formation and maintenance; these changes apparently were enhanced by low dietary magnesium. Changes caused by boron deprivation included depressed plasma ionized calcium and calcitonin as well as elevated plasma total calcium and urinary excretion of calcium. In one human study, magnesium deprivation depressed plasma ionized calcium and cholesterol. Because boron and/or magnesium deprivation (http://www.ncbi.nlm.nih.gov/pubmed/2222801)causes changes similar to those seen in women with postmenopausal osteoporosis, these elements are apparently needed for optimal calcium metabolism and are thus needed to prevent the excessive bone loss which often occurs in postmenopausal women and older men."
"Evidence from numerous laboratories using a variety of experimental models, including humans, shows that boron is a bioactive beneficial element. Much evidence has come from studies that did not require nutritional or environmental stressors or fastidious methods in diet preparation or environmental control. The evidence includes deprivation studies showing that boron is necessary for some higher animals to complete the life cycle, and that realistic low boron intakes result in impaired bone health, brain function, and immune response (http://www.ncbi.nlm.nih.gov/pubmed/18366532). Thus, low boron intake is a relevant nutritional concern, which diets rich in fruits, vegetables, nuts, and pulses can prevent."
"Minerals associated with bone organic matrix, zinc and potassium, were increased by boron supplementation in tibia. Plasma phospholipids were decreased by boron deprivation in females, but not males. Plasma cholesterol was decreased in boron-supplemented males by replacing canola oil with palm oil. The findings suggest that a diet high in omega-3 alpha-linolenic acid promotes femur strength best when the dietary boron is adequate. (http://www.ncbi.nlm.nih.gov/pubmed/15665386)..."
"there is considerable evidence that both compositional and functional properties of bone are affected by boron (http://www.ncbi.nlm.nih.gov/pubmed/7889880)status"
but also impacting on that is Zinc. (http://www.ebmonline.org/cgi/reprint/229/4/303)
Vitamin K (http://jn.nutrition.org/cgi/reprint/125/7/1812), vitamin K (http://www.ajcn.org/cgi/reprint/80/4/1075), and vitamin K applying to both men and women (http://jcem.endojournals.org/cgi/reprint/89/10/4904). which is what you'd expect because vitamin K forms a mineral bond with calcium and phosphorus, and pulls them into that base matrix.
Other dietary components, such as protein, magnesium, zinc, copper, iron, fluoride, vitamins D, A, C, and K (http://www.jacn.org/cgi/content/full/19/6/715) are required for normal bone metabolism,.. more on protein (http://www.jacn.org/cgi/content/full/24/suppl_6/526S). Protein consumption is an important predictor (http://jn.nutrition.org/cgi/content/full/137/12/2674) of lower limb bone density in older women. Protein is important in bone building particularly in vegetarians, because collagen is made from complete amino acids. So vegetarians must take particular care when putting combining foods to create complete amino acids, so that the body can take from it to make collagen. Those who eat chicken, meat etc, have a complete protein handed them on a plate, particularly if they have bone broths, and gelatine broths. Protein in the absense of calcium (http://jn.nutrition.org/cgi/reprint/137/12/2674)(and other minerals) means that it doesn't quite "work"... you might get collagen formatin, but the mineral matrix will be weak. Even tea drinking (http://www.ajcn.org/cgi/content/full/86/4/1243), conveys minerals like manganese, which are beneficial to bones.
http://www.health-science-spirit.com/magnesiumchloride.html
"Medical authorities claim that the widespread incidence of osteoporosis and tooth decay in western countries can be prevented with a high calcium intake. However, published evidence reveals that the opposite is true. Asian and African populations with a very low intake of about 300 mg of calcium daily have very little osteoporosis. Bantu women with an intake of 200 to 300 mg of calcium daily have the lowest incidence of osteoporosis in the world. In western countries with a high intake of dairy products the average calcium intake is about 1000 mg. The higher the calcium intake, especially in the form of cows' milk products (except butter) the higher the incidence of osteoporosis.
Calcium, magnesium and phosphorus levels are kept in a seesaw balance by the parathyroid hormones. If calcium goes up, magnesium goes down and vice versa. With a low magnesium intake, calcium goes out of the bones to increase tissue levels, while a high magnesium intake causes calcium to go out of the tissues into the bones. A high phosphorus intake without a high calcium or magnesium intake causes calcium to leach from the bones and leave the body with the urine. A high phosphorus intake with high calcium and magnesium leads to bone mineralisation.
Dr Barnett, an orthopaedic surgeon practised in two different U.S. counties with very different soil and water mineral levels. In Dallas County with a high calcium and low magnesium concentration osteoporosis and hip fractures were very common, while in Hereford with high magnesium and low calcium these were nearly absent. In Dallas County the magnesium content of bones was 0.5% while in Hereford it was 1.76%. In another comparison the magnesium content in bones of osteoporosis sufferers was 0.62% while in healthy individuals it was 1.26%.
The same applies for healthy teeth. In a New Zealand study it was found that caries-resistant teeth had on average twice the amount of magnesium as caries-prone teeth. The average concentration of magnesium phosphate in bones is given as about 1%, in teeth about 1.5%, in elephant tusks 2% and in the teeth of carnivorous animals made to crush bones it is 5%. In regard to the strength of bones and teeth think of calcium as chalk and of magnesium as superglue. The magnesium superglue binds and transforms the chalk into superior bones and teeth."
Too much preformed vitamin A (http://folk.uio.no/runeb/pdf%20filer/Vitamin%20A%20toxicity.PDF) causes serious bone problems (http://www.ajcn.org/cgi/content/full/83/2/191), but remember, if you are doing the balance with vitamin D, vitamin C and exercise right, that's not an issue (http://jn.nutrition.org/cgi/reprint/129/12/2246.pdf). At least in rats :giggle: .
the key to good strength in bones is vitamin K and minerals from fruit and veges (http://www.ajcn.org/cgi/content/full/82/3/700): no doubt about it.
So why the concentration by doctors on calcium alone? And just how many people on calcium supplements show much real improvement? If you carry on shoving in calcium all the time, you pull OUT the magnesium. If you're not eating enough calcium in the first place, and some doctors estimate that that's 70% of the western population, that too causes pullout of calcium from the bones, which is then depositted in soft tissue, which doesn't just harden the arteries, but can harden heart muscles and do a whole raft of nasty things.
With kids, or adults, you never know when someone is going to break a bone, but if that happens, it's important to know what to do and why.
And to understand what to do and why, you have to know HOW bone is made in the first place. it's actually very fascinating.
Bearing in mind that, as this 2006 study (http://www.ismni.org/jmni/pdf/26/27DALLAS.pdf) says, there is a lot they don't know about bone growth :giggle: :giggle:
these studies suggest that cells within the bone environment may be more dynamic than previously thought and highlight novel cell-mediated mechanisms for the assembly and subsequent reorganization of the ECM.
I believe that the fundamentals above, are probably stuff in retrospect, that you already know yourself.
So if you eat a Standard American Diet, think again, because you might not just be heading for osteo yourself, but you could donate problems to your children.
All that... is called.... epigenetics :p
Now, do not complain of brain fag :D