Polio from vaccine: India confirms two cases

[Dozytoes]

http://www.indianexpress.com/news/Polio-from-vaccine--India-confirms-two-cases/475202
Polio from vaccine: India confirms two cases



http://www.indianexpress.com/news/Polio-from-vaccine--India-confirms-two-cases/[Insert%20file%20path%20here]/1x1.GIF (http://ad.in.doubleclick.net/click;h=v2%7C3AFB%7C0%7C0%7C%2a%7Ct;214094634;0-0;0;36480465;31-1%7C1;31131442%7C31149318%7C1;;%3fhttp://www.emailwithease.com) http://ad.in.doubleclick.net/imp;v1;f;214094634;0-0;0;36480465;1%7C1;31131442%7C31149318%7C1;;cs=b%3 fhttp://ad.in.doubleclick.net/dot.gif?[timestamp]

Posted: Friday , Jun 12, 2009 at 0157 hrs IST




TEENA THACKER & SAMUDRA GUPTA KASHYAP NEW DELHI/GUWAHATI:


For the first time ever, India has confirmed two separate cases of vaccine-derived poliovirus (VDPV). The cases have been reported in a four-year-old boy in Assam’s Dibrugarh district and a two-year-old in Bihar’s Champaran district. VDPVs are strains of the virus contained in the oral polio vaccine which have changed and reverted to a form that can cause paralysis in humans with the capacity for sustained circulation.



Experts said VDPVs are “very rare” but there is nothing to worry. “They have been seen in many countries. Many VDPVs are isolate that do not progress any further. Those that do circulate respond readily to high quality immunisation response,” said Dr Hamid Jafari, project manager, WHO, National Polio Surveillance Project.



While the two cases are not related, investigations to determine the immunological and clinical status of both have been initiated. “The two cases are being investigated for any immunodeficiency disorder which may be the reason for the VDPV. Usually, it is seen in one having immunodeficiency or in areas with low population immunity,” said Dr Sunil Khaparade, Deputy Commissioner, Immunisation, Union Health Ministry.

[Momtezuma Tuatara]

It's not unusual in India. VDPDs are rife.

http://www.bmj.com/cgi/eletters/336/7647/750#193382 (http://www.bmj.com/cgi/eletters/336/7647/750#193382)

As is happening right now in Africa. Much of the polio running through Africa right now, is VDPD. (I put that up elsewhere)

[ema-adama]

Experts said VDPVs are “very rare” but there is nothing to worry. “They have been seen in many countries. Many VDPVs are isolate that do not progress any further. Those that do circulate respond readily to high quality immunisation response,” said Dr Hamid Jafari, project manager, WHO, National Polio Surveillance Project.

Why would they say that VDPV's respond well to high quality vaccination response? I take it that means rounding all the children up and vaccinating them with OPV again, regardless of vaccination status and present immunity?

With VDPV's, it's a mutation of the virus. Is the virus mutating back to it's 'original form'? or is it a new form? I am wondering how well the present OPV can work on VDPV's? Or if that is what is available, so that is what is used?

I know there are VDPV's here in Israel in the sewage, but I have not heard of anyone diagnosed with it.

There was a case of it about a month ago in Argentina.....

Am I correct in guessing that a healhty gut is a good first line of defense against any polio virus, VDPV or otherwise?

[Momtezuma Tuatara]

Why would they say that VDPV's respond well to high quality vaccination response? I take it that means rounding all the children up and vaccinating them with OPV again, regardless of vaccination status and present immunity?Yup.


With VDPV's, it's a mutation of the virus. Is the virus mutating back to it's 'original form'? or is it a new form?they call it "reverting to virulance" i.e. going back to the wild state. The virus is changed by growing it on tissue it's not naturally growing on, so it changes to adapt by changing it's DNA so that it can survive in that media. They don't know how that's done, ... they just know that the genome changes. then when it gets back into its natural host, it reverts to the genome sequences that lives most efficiently in that host.


I am wondering how well the present OPV can work on VDPV's? Or if that is what is available, so that is what is used?they don't know any other way. So they flood the environment with vaccine viruses, and hope that floods out the reverted strains...


I know there are VDPV's here in Israel in the sewage, but I have not heard of anyone diagnosed with it. Because one of the keys is nutrition. :giggle: funny that....


There was a case of it about a month ago in Argentina.....

Am I correct in guessing that a healhty gut is a good first line of defense against any polio virus, VDPV or otherwise?Absolutely!!!

You've got it in one :D healthy gut, great diet, minimal sugar and no junk...

[ema-adama]

Yup.

they call it "reverting to virulance" i.e. going back to the wild state. The virus is changed by growing it on tissue it's not naturally growing on, so it changes to adapt by changing it's DNA so that it can survive in that media. They don't know how that's done, ... they just know that the genome changes. then when it gets back into its natural host, it reverts to the genome sequences that lives most efficiently in that host.
I remember reading somewhere that it is all the fault of people who partially vaccinate their children as you have to have 3-4 doses to be fully immune and people who only get 1-2 doses create the optimal environment for genome changes. Is there any truth to that? It was in a discussion about antibiotics and how parents who do not finish a course of antibiotics are causing antibiotic resistant bacteria.

I am also curious as to why vaccinating already vaccinated children would even be theorised to be helpful. Are there any numbers on primary vaccine failure of OPV that would lead doctors to think that a new round in an already vaccinated population would make a difference.



they don't know any other way. So they flood the environment with vaccine viruses, and hope that floods out the reverted strains...
Sounds like hit and miss :giggle:- or is this the science that parents don't understand and need to ask doctors to explain to them?


Because one of the keys is nutrition. :giggle: funny that....

Absolutely!!!

You've got it in one :D healthy gut, great diet, minimal sugar and no junk...I have been thinking this is probably our best bet. I was talking to my friend who is a TCM doctor and he was talking about layers of immunity - which helped my mind get an image - I always understand better with an image. So, mucosal linings in the body are the first layer of defense and there are I think 7 layers from what I remember, with the last being the antibodies in the blood. I'll have to ask him some more about that. Like I said, I like the image. One day when I have the time, I want to figure out Ig and which types are found where and see if it corresponds with the idea of layers of immunity :alien: